Vitamin PP is used to treat and prevent the lack of natural vitamin PP in the body. Lowers cholesterol and triglycerides (types of fat) in the blood. Helps reduce the risk of heart attack in people with high blood cholesterol who have a history of heart attack. In addition, Vitamin pp also has a number of other uses, but you should only use it as prescribed by your doctor. Let’s refer to the article through the sharing of 2bacsi!
What is Vitamin PP
?What is Vitamin PP? This is a vitamin of the B group, also known as vitamin B3. The active ingredient is nicotinic acid (niacin) or nicotinamide (the amide form of nicotinic acid).
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Vitamin PP plays an important role in converting food into usable energy. Helps the body’s cells carry out important chemical reactions. Since it is water soluble, the body does not store this vitamin. This is why we need to eat foods that contain nicotinic acid or niacinamide daily.
Vitamin B3 is commonly found as niacinamide in meat products, such as pork and poultry. Nicotinic acid in foods such as seeds, flours and green vegetables. Many refined grain products are also high in niacinamide.
Our bodies can also make vitamin PP from tryptophan, an amino acid found in most protein foods.
Pharmacology of Vitamin PP
In the body, nicotinamide is made up of nicotinic acid. In addition, some of the tryptophan in the feed is oxidized to nicotinic acid and then to nicotinamide.
Nicotinamide and nicotinic acid are B vitamins, water soluble, found in many foods such as yeast, meat, fish, milk, eggs, green vegetables, and cereal grains. cereals exist in a form that is difficult to absorb.
Nicotinamide and nicotinic acid available on the market are chemically synthesized products.
In vivo, nicotinamide functions after conversion to either nicotinamide adenine dinucleotide (NAD) or nicotinamide adenine dinucleotide phosphate (NADP).
NAD and NADP have a vital role in metabolism, as a coenzyme that catalyzes redox reactions essential for cellular respiration, glycogenolysis, and lipid metabolism. In such reactions these coenzymes act as hydrogen carriers.
If the body lacks nicotinamide, it can cause pellagra. Which may be due to a lack of nicotinamide in the diet. Either due to isoniazid treatment, or due to decreased conversion of tryptophan to nicotinic acid in Hartnup’s disease, or due to malignancy. Because these tumors use large amounts of tryptophan to synthesize 5-hydroxytryptophan and 5-hydroxytryptamine.
A lack of nicotinamide can occur with a deficiency of other B-complex vitamins.
The major organs affected by nicotinamide deficiency are the gastrointestinal tract, skin, and central nervous system. Taking nicotinamide or nicotinic acid will relieve symptoms caused by deficiency.
The symptoms of redness and swelling of the tongue in people with pellagra should go away within 24 to 72 hours of taking nicotinamide. Psychiatric symptoms, infections of the mouth and other mucous membranes will clear up quickly. Gastrointestinal symptoms resolve within 24 hours.
Nicotinic acid causes the release of histamine, which leads to increased gastric motility and increased acid secretion; It also activates the fibrinolytic system. High doses of nicotinic acid reduce uric acid excretion and decrease glucose tolerance.
Pharmacokinetics of vitamin PP
Nicotinamide is rapidly absorbed from the gastrointestinal tract after oral administration and is widely distributed into body tissues.
Nicotinic acid is present in human milk. The elimination half-life of the drug is about 45 minutes.
Nicotinamide is metabolized in the liver to N – methylnicotinamide, 2 – pyridone and 4-pyridone derivatives, and also to nicotinuric.
Following administration of nicotinamide at usual doses, only a small amount of nicotinamide is excreted unchanged in the urine.
However, with large doses, the amount of drug excreted unchanged will increase.
Uses of Vitamin PP
Vitamin PP, also known as nicotinic acid, is a commonly used B vitamin (vitamin B3) in 500mg strength. Vitamin PP is found in plants and animals.
Vitamin PP 500mg is used to treat and prevent natural vitamin PP deficiency in the body, reduce cholesterol and triglycerides (types of fat) in the blood.
Vitamin PP is also used to reduce the risk of heart attack in people with high blood cholesterol who have had a heart attack.
Sometimes, vitamin PP is used to treat atherosclerosis.
Who is vitamin pp indicated for
The following subjects will be prescribed vitamin pp by a doctor:
Prevention of Nicotinamide deficiency.Pellagra disease treatment with manifestations: Symmetrical dermatitis of the legs and open areas, initially red spots after crusting. Glossitis, tongue ulcers, esophagitis, gastroenteritis , increased salivation, loose stools. Insomnia, headache, depression, confusion, memory disorders, possible dementia (hallucinations, paranoia).
Dose and dosage of the drug
The next content is just for reference only. You should absolutely not use it without your doctor’s prescription. Because each condition will have a different dose. Specifically:
Dosage of vitamin PP for adults
Usual Adult Dose for Vitamin PP Deficiency: 10-20mg once daily.
Vitamin PP can also be injected topically as a form of multivitamin.
Dosage of vitamin PP for children
Boys 14-18 years old: 16mg orally per day.
Girls 14-18 years old: 14mg orally per day.
How to use
You should use vitamin PP exactly as directed on the label or as directed by your doctor.
Do not use the medicine in larger or smaller amounts or for longer than prescribed.
Vitamin PP should be taken at bedtime with a low-fat snack.
If you have any questions while using this medicine, ask your doctor or pharmacist.
In the event of an emergency or overdose, immediately call 911 or go to the nearest local health station.
Also, you need to keep a record and bring a list of all the medicines you have taken. Includes both prescription and over-the-counter drugs.
When an overdose, the doctor will use the usual measures such as: induce vomiting; gastric lavage; Symptomatic and supportive treatment.
If you forget to take a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take double the prescribed dose.
The drug is contraindicated for whom
Not everyone can use Vitamin PP pills. The following subjects are contraindicated with the drug:
Hypersensitivity to nicotinamide.Severe liver disease.Progressing gastric ulcer.Arterial hemorrhage.Severe hypotension.
Side effects when taking vitamin PP
Vitamin pp rarely occurs side effects. However, if you experience any of the following unwanted side effects, call your doctor right away:
Fast or irregular heartbeat; Shortness of breath; Swelling; Yellow skin or eyes; Muscle pain, allergies or symptoms of fever or flu and dark urine.. Mild dizziness; Warm, red, or sensational skin Tingling under the skin; Itching, dry skin; Sweating or chills; Nausea, diarrhea, belching; Muscle pain, leg cramps; Sleep problems (insomnia). If you have diabetes, take it. Tell your doctor about any changes in your blood sugar
This is not a complete list of side effects and others may occur. If you have any questions about side effects, consult your doctor or pharmacist.
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Caution when using vitamin pp 500mg pharmedic
When using high doses of nicotinamide for the following cases: History of peptic ulcer, gallbladder disease, history of jaundice or liver disease, gout, gouty arthritis, and diabetes.
Pregnancy: Using nicotinamide in dietary supplements for pregnant women does not cause harm to the mother and fetus.
Lactation: Administration of nicotinamide in supplemental doses to the diet of nursing mothers is unlikely to cause any harm to the mother or the nursing infant. Nicotinamide should be used as a supplement to the diet of nursing mothers when the diet is not adequate for nicotinamide.
Use for driver and machine operator: suitable for driver and machine operator.
With drugs to treat high blood pressure: vitamin PP is a vasodilator, often causing flushing and lowering blood pressure. Therefore, avoid combining vitamin PP with antihypertensive drugs because it can cause excessive lowering of blood pressure
With hypoglycemic drugs: vitamin PP breaks down glycogen, so it increases blood sugar. Therefore, people with diabetes should pay attention to adjust the dose when combined with vitamin PP.
The group of statin drugs (HGM-CoA reductase inhibitor group: such as Simvastatin, Lovastatin …) when combined with vitamin PP can increase the risk of causing rhabdomyolysic.
Group of drugs that combine bile acids: (such as Colestipol, Colesevelan, Cholestyramine…) vitamin PP will reduce the effect, so it should be noted that they must be used far away from these drugs.
With drugs that cause hepatotoxicity: vitamin PP with doses >3g per day in adults will cause hepatotoxicity. The combination of vitamin PP with hepatotoxic drugs should be avoided.
With Carbamazepine (antiepileptic drug): vitamin PP increases the concentration of Carbamazepine, leading to increased toxicity for the body. Avoid taking these two drugs together
With anticoagulants: should be avoided, because vitamin PP increases the effect of the drug, increases the risk of bleeding.
With tetracycline antibiotics: should be avoided at the same time, because vitamin PP reduces the absorption and effectiveness of the drug.
With Isoniazid (INH) as a medicine for tuberculosis, INH reduces nicotinic acid in the body. Therefore, it is necessary to pay attention to supplement vitamin PP with adequate nutrition or with drugs during long-term treatment with INH.
For people with gout: vitamin PP in high doses reduces uric acid excretion. Therefore, it is necessary to be cautious when using high doses of vitamin PP in people with a history of gout.
Undesirable effects when using vitamin pp pharmacopoeia
Usually, small doses of nicotinamide are not usually toxic. However, if high doses are used, as in the case of:
In the treatment of pellagra, the following side effects may occur, which will go away after stopping the drug.
Common, ADR > 1/100
Other: Flushing of the face and neck, itching, burning, stinging or stinging sensation in the skin.
Gastrointestinal: Progressive gastric ulcer, vomiting, anorexia, pain on hunger, flatulence, diarrhea.
Skin: Dry skin, hyperpigmentation, jaundice.
Metabolism: Liver failure, impaired glucose tolerance, increased sebaceous gland secretion, exacerbation of gout.
Other: Hyperglycaemia, hyperuricemia, vagal-vascular attack, headache and blurred vision, hypotension, dizziness, tachycardia, syncope.
Anxiety, panic, glucoseuria, abnormal liver function, abnormal prothrombin time, hypoalbuminemia, anaphylaxis.
Instructions on how to handle ADR
In most patients receiving high-dose drugs such as those used to treat pellagra, flushing of the face and neck (in areas prone to redness) is common, and is related to the rate of increase in serum concentrations rather than to the total serum concentration of the drug.
To limit such side effects, the drug should be taken with food, gradually increased dose, or used the extended-release formulation of the active ingredient.
It is necessary to periodically monitor and monitor early in the course of treatment for blood glucose, liver function for patients on long-term treatment with nicotinamide or nicotinic acid with doses exceeding physiological needs.
Stop taking the medicine and consult a doctor immediately if you have any of the following symptoms: Flu-like symptoms (nausea, vomiting, general unwell feeling), decreased urine output and urine that is dark in color, difficulty muscle problems such as: muscle swelling, tenderness or weakness, an irregular heartbeat, or blurred, cloudy vision.
Some notes before you take vitamin pp
Before taking this medicine, you should tell your doctor or pharmacist if:
You are pregnant or breastfeeding. You need to take the medicine prescribed by your doctor in this case; You are allergic to any of its ingredients; You are taking other medications (including prescription and over-the-counter medicines, herbs and foods) supplements); You plan to give the drug to children or the elderly; You have or have ever had medical conditions.
To make sure you take vitamin PP 500mg safely, tell your doctor if you have any of the following conditions:
Liver or kidney disease; Heart disease or uncontrolled angina; Stomach ulcers; Diabetes; Gout; Muscle disorders such as myasthenia gravis.
There are not enough studies to determine the risks of taking this medicine during pregnancy or breast-feeding. Before taking medication, always consult with your doctor to weigh the benefits and risks.
Interaction of vitamin pp with drugs
Vitamin PP may change how other medicines you are taking work or increase the effects of side effects. To avoid drug interactions, it’s best to write down a list of all the medications you’re taking (including prescription, over-the-counter, herbal, and dietary supplements) and show them to your doctor or pharmacist. To ensure safety when taking the drug, do not arbitrarily take the drug, stop or change the dose of the drug without the permission of your doctor.
Currently, vitamin pp is interacting with drugs such as:
Concomitant use of nicotinamide with an HGM-CoA reductase inhibitor may increase the risk of rhabdomyolysis. Concomitant use of nicotinamide with an alpha-adrenergic blocker for hypertension may lead to hypotension. The dietary intake and/or dose of oral hypoglycemic agents or insulin may need to be adjusted when used concomitantly with nicotinamide. Concomitant use of nicotinamide with hepatotoxic drugs may further increase the risk. Hepatotoxic effects. Nicotinamide should not be used concurrently with carbamazepine because it causes increased plasma carbamazepine concentrations leading to increased toxicity.
Instructions on how to preserve vitamin PP
To prevent the drug from spoiling and reducing its effectiveness. You should:
Store at room temperature, away from moisture and light.Do not store in the bathroom or in the freezer. You should remember that different storage methods may be required for each medicine. Therefore, you should read the packaging instructions carefully or ask the pharmacist. Keep the medicine out of the reach of children and pets. Do not throw the medicine down the toilet or plumbing unless directed to do so. Instead, dispose of medicines properly when they are past their expiration date or unusable. You can consult your pharmacist or local waste company about how to safely dispose of them.
So how to supplement vitamin PP for the body
?One of the most effective ways to supplement vitamin PP in the body is to choose foods rich in vitamin PP to supplement daily meals. day.
You can also get vitamin B through some foods:
Cashews are rich in vitamin B3, vitamin B1, and vitamin B6. The nut has an attractive taste that is not only rich in vitamins but also rich in energy supply for the body.Almonds are rich in vitamin B3, vitamin B1, vitamin B5, B9, B6. In addition, almonds also contain vitamin E, magnesium, iron and protein. You can eat raw or roasted almonds in combination with a glass of almond milk to supplement the source of vitamins and nutrients for the body. Avocado is rich in vitamin E, magnesium, and B vitamins, namely vitamin PP, vitamins B5, B6.
Avocados help the body produce glutathione, a powerful antioxidant that helps prevent aging, memory loss, cardiovascular disease, and cancer.
Avocados also help lower cholesterol, blood pressure and reduce stress.
In addition, it helps prevent bloating due to its high potassium content.
Oats are fortified with vitamin B5, vitamin B1, vitaminPP, vitamin B2 and vitamin B6 for the body. Oats are also rich in fiber and can help maintain healthy cholesterol levels. Using pulses for breakfast will help you get a great source of energy to function throughout the day. In addition to the foods mentioned above, vitamin PP is found in foods such as fish, rice, barley, potatoes, milk, cheese, tofu, butter, beans, mushrooms, spinach, eggs, mackerel, chicken, shrimp… Besides the above natural foods. Vitamin B3 is also synthesized in the form of functional food tablets, you should consult and follow the instructions of your doctor. The use of the drug can cause some unwanted side effects such as causing vasodilation in the face and upper half. The body causes hot flashes, dizziness, nausea. In order not to be deficient in vitamin PP, we need to have a reasonable diet, ensuring the amount of protein for the body to synthesize vitamin PP. In addition, not Should abuse antibiotics because it will cause intestinal dysbacteriosis, reduce the absorption of vitamin PP.
Above are a few side effects when using Vitamin pp. It is possible that you will experience side effects that are not listed. If you encounter any unusual signs while using vitamin pp. Please notify your doctor immediately for timely solutions.
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Note: The information shared by 2bacsi in the above article is for reference only. Please use vitamin pp medicine exactly as directed by your doctor. To avoid causing unwanted effects, at the same time protect your health and stay healthy.